BRCA1 and breast carcinoma: In breast cancer patients, there were 21 pathogenic variants, 4 likely pathogenic variants, and 30 VUS in BRCA1, and 23 pathogenic variants, 2 likely pathogenic variants, and 46 VUS in BRCA2. In ovarian cancer patients, there were 17 pathogenic variants, 3 likely pathogenic variants, and 7 VUS in BRCA1 and 8 pathogenic variants and 10 VUS in the BRCA2 (Fig. 3D).