Variants in exon 11 of BRCA2 were detected in 57 breast cancer patients and 12 ovarian cancer patients; this was the most frequently mutated exon of BRCA2. The next most common exons of BRCA2 with variants were exon 15 (7 breast cancer patients and 1 ovarian cancer patient) and exon 10 (6 breast cancer patients) (Fig. 2B). This evidence concerns the gene BRCA2 and breast cancer.