For those TCGA tumors with missing normal tissue data, we acquired the normal tissue data of the GTEX dataset and used them as a control group to further analyze the expression differences of APOBEC3B in normal tissues and tumor tissues of Adrenocortical carcinoma (ACC), acute myeloid leukemia (LAML), OV, testicular germ cell tumors (TGCT), uterine carcinosarcomas (UCS), brain lower grade gliomas (LGG), skin cutaneous melanomas (SKCM) and thymomas (THYM) (Fig. 1b , P < 0.001). This evidence concerns the gene APOBEC3B and acute myeloid leukemia.