Missense mutations were found to be the main type of APOBEC3B genetic alterations: an R114H/S alteration in the APOBEC-like N-terminal domain, which was detected in one case of GMB, one case of PRAD and one case of STAD (Fig. 3b), and a P355S alteration in APOBEC-like C-terminal domain, which was detected in one case of LUSD and two cases of SKCM. Here, APOBEC3B is linked to prostate adenocarcinoma.