NOX1 and inflammatory response: These results coincide with the findings by Xu et al., in which wild type mice fed high-fat-high sucrose (HFHS) diet demonstrated an increase in Mac-2, IL-1β and nitrosative stress in cardiac tissue by comparison to NOX-1 knockout mice, indicating that NOX1 contributes to oxidative stress, endothelial activation and myocardial inflammation [54].