In another study, overexpression of MIOX led to worsening of AKI in cisplatin-induced injury, and disruption in MIOX gene seemed to be protective against cisplatin-induced AKI20, Further, in type 2 diabetic nephropathy (T2DN), expression of MIOX correlates with tubulointerstitial damage21 A few studies have explored pathways that might explain the mechanism of the role of MIOX in AKI-CKD progression. This evidence concerns the gene MIOX and type 2 diabetes nephropathy.