Using transmission family-based approaches, we saw an association of AD risk with PILRA R78G (p = 0.0495) and APOE rs429358 (ε4, p = 1.78 × 10−15) and rs7412 (ε2, p = 5.01 × 10−5) SNPs, but not with GM17 (rs1071803, p = 0.9). The gene discussed is APOE; the disease is Alzheimer disease.