We found negative interactions between PILRA R78G-A x GM17 and PILRA R78G-A x APOE risk variants (ε3/ε4 or ε4/ε4) for the risk of AD (OR for the interaction 0.72, 95% CI 0.52–1.00 and 0.56, 95% CI 0.32–0.98 respectively; Table 3). The gene discussed is APOE; the disease is Alzheimer disease.