On the one hand, hypoxia leads to a transcriptional program promoting basement membrane degradation, while increasing the ab initio synthesis of protofibrillar collagen as a physical pathway of tumor invasion58,59; on the other hand, hypoxia is a potent promoter of tumor-associated angiogenesis60, which was significantly activated in the high TBC1D8 expression group in the GSVA. The gene discussed is TBC1D8; the disease is neoplasm.