COPD-specific genes (CORIN, SELL, SH3PXD2B) and LUAD-specific critical genes (ASPM, CENPF, MAD2L1, TOP2A, CDKN2A, ELF3, IGFBP2) were expressed at higher levels in comparison to normal controls. This evidence concerns the gene CDKN2A and chronic obstructive pulmonary disease.