COPD-specific genes (CORIN, SELL, SH3PXD2B) and LUAD-specific critical genes (ASPM, CENPF, MAD2L1, TOP2A, CDKN2A, ELF3, IGFBP2) were expressed at higher levels in comparison to normal controls. The gene discussed is SH3PXD2B; the disease is chronic obstructive pulmonary disease.