Intestinal NPC1L1 is differentially expressed in the gastrointestinal tract, with much higher levels in small intestine than colon, which is associated with high levels of methylation upstream of NPC1L1 gene start site in the colon, suggesting a possible reduction in cholesterol uptake and prevention of atherosclerosis by alteration of DNA methylation.177 Whereas data on the epigenetic regulation of ABCG5/8 in the intestine are very limited. The gene discussed is NPC1L1; the disease is atherosclerosis.