MAPT and hyperinsulinemic hypoglycemia, familial, 4: A case-control study found a significant tau deposition in the brains of Niemann-Pick type C patients.456 CE are the major storage form of excess cholesterol, and Kant et al. found that CE inhibited pTau degradation by inhibiting proteasome activity.457 Conversely, Fan et al. demonstrated that cholesterol deficiency also leads to tau hyperphosphorylation,458 indicating the exact mechanism of cholesterol effects on p-Tau remains to be further explored.