Genomic analysis reveals increased risk of CVD in loss-of-function carriers of scavenger receptor class B member 1 (SCARB1) variant, which encodes SR-BI, suggesting the protective role of SR-BI in atherosclerosis.353 Given the recent appreciation of endothelial SR-BI in LDL transcytosis, SR-BI targeted therapies need to be assessed with caution.354 At present, the mechanism by which SR-BI works in human body is still unclear, so exploring its detailed mechanism is crucial for the development of new treatments for atherosclerosis. Here, SCARB1 is linked to atherosclerosis.