However, LXR is inhibited in tumors, which contributes to cholesterol accumulation in cancer cells.512,513 Interestingly, CE levels were also significantly increased in tumors.513,514 ACAT involves in synthesis of CE, which has been shown to be associated with a variety of tumors.513,515 A latest study found that loss of P53 increased ubiquitin specific peptidase 19, which in turn stabilized ACAT1 and led to CE accumulation.516 This study provides an important mechanism indicating the involvement of CE in hepatocellular carcinogenesis. Here, ACAT1 is linked to cancer.