It promotes uptake of oxLDL by ECs, VSMCs, monocytes and macrophages, resulting in foam cell formation.342 At the same time, some studies have shown that LOX-1 deletion significantly reduces oxidative stress, nitric oxide degradation and inflammatory responses, reducing the progression of atherosclerosis.343,344 Therefore, it is suggested that LOX-1 promotes the atherosclerosis progression. The gene discussed is OLR1; the disease is atherosclerosis.