OLR1 and atherosclerosis: Currently, some natural products, such as Tanshinone II-A, curcumin and Gingko biloba extract, have been shown to prevent atherosclerosis through LOX-1 inhibition.346–348 The LOX-1 molecule consists of a hydrophobic channel that is the primary binding site for the phospholipid moiety of oxLDL.349 Chemically synthesized small molecules targeting this channel can effectively reduce oxLDL uptake in vitro.350 In addition to chemically synthesized inhibitors, many monoclonal antibodies are available to block LOX-1 activity.