Among them, SR-A1 and CD36 mediate most of the endocytosed LDL (75–90%).91–93 Meanwhile, compared with LDL, these scavenger receptors have higher affinity for modified LDL, particularly the oxidatively modified LDL (oxLDL).94 In atherosclerosis, expression of SR-A1, LOX-1, and CD36 in macrophages are increased. This evidence concerns the gene SRA1 and atherosclerosis.