SH3RF2 and metabolic dysfunction-associated steatotic liver disease: Yang et al. found that knockout of E3 ligase SH3 domain-containing ring finger 2 (SH3RF2) in hepatocytes resulted in accumulation of acetyl-CoA, which directly promoted cholesterol synthesis and aggravated the development of NAFLD.405 Furthermore, miRNAs are key factors in regulating hepatic cholesterol synthesis.406 Targeting SH3RF2 or miRNAs may be a new approach to alleviate NAFLD by lowering cholesterol.