Moreover, we used a luciferase/GFP/Nalm6-breaing mouse leukemia model to test the reverse efficacy of BET inhibitor on T-cell exhaustion (Fig. 7J), and found that in all treated mice, CAR T cells pretreated by JQ1 produced a significantly lowed tumor burden and longer remission, as well as prolonged survival, compared with the control group (Fig. 7K–N). The gene discussed is DNER; the disease is leukemia.