HECTD3 and neoplasm: Finally, we inhibited expression of E-selectin, ICAM-1 and VCAM-1 using a siRNA mixture of siE-selectin, siICAM-1 and siVCAM-1, which blocked upregulation of expression of these adhesion molecules (Supplementary Fig. 2k), as well as the increase in tumor cell adhesion (Fig. 2i, j) induced by HECTD3 overexpression in HUVECs.