Finally, we inhibited expression of E-selectin, ICAM-1 and VCAM-1 using a siRNA mixture of siE-selectin, siICAM-1 and siVCAM-1, which blocked upregulation of expression of these adhesion molecules (Supplementary Fig. 2k), as well as the increase in tumor cell adhesion (Fig. 2i, j) induced by HECTD3 overexpression in HUVECs. This evidence concerns the gene VCAM1 and neoplasm.