E-selectin−/− mice show bone metastasis blockade.9 Ang2 (angiopoietin-2) increases ICAM-1 expression in ECs so that anti-Ang2 therapy limits the outgrowth of micrometastases.32 Anti-VCAM-1 or anti-integrin α4 mAbs also dramatically reduced bone metastasis in breast cancer.13 Here, we showed that HECTD3 and IKKα control inflammatory adhesion molecule expression and that inhibition of HECTD3 genetically or IKKα pharmacologically suppresses metastasis induced by acute inflammation. The gene discussed is HECTD3; the disease is breast carcinoma.