More importantly, the role of BHB-Hopx pathway in CRC treatment was also found in organoids cultured with human healthy or patient intestinal crypts, and clinical data displayed a strong relevance between serum BHB, colonic Hopx levels, and cell cycle, which implied that manipulation of BHB-Hopx pathway may be a potential effective way for CRC treatment. This evidence concerns the gene HOPX and colorectal carcinoma.