Moreover, given that Hopx was specifically elevated in colonic tissue of KD-fed mice, and could respond to BHB only in a few CRC cell lines, together with the actuality that KD has been clinically applied in epilepsy for many years, KD-based multiple combination strategies offer a variety of options for personalized treatment in patients with CRC, especially in the type of BHB-Hcar2-Hopx axis high responsiveness. Here, HOPX is linked to colorectal carcinoma.