To recapitulate briefly, the circ_0000317 expression level declined in NSCLC tissues and cells, which is related to the malignant clinical features of NSCLC patients, and circ_0000317/miR-494-3p/PTEN/PI3K/AKT axis is implicated in the pathogenesis of NSCLC. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.