LIPA and cancer: Interestingly, data mining analyses of the TCGA database revealed downregulation of LAL gene expression in various human cancer forms, including Breast Cancer (BRCA), Kidney Chromophobe (KICH), LUAD, LUSC, Pancreatic Adenocarcinoma (PAAD), SKCM, and Uterine Corpus Endometrial Carcinoma (UCEC) (Figure 7L).