Perhaps more importantly, we also showed that in the Lepob/ob mouse model of T2D, NPY/AgRP neuronal activity remained inhibited for at least 2 weeks following a single i.c.v. injection of FGF1 (relative to i.c.v. vehicle-injected controls) and, furthermore, that the underlying mechanism involved increased synaptic input from upstream GABAergic neurons. Here, AGRP is linked to type 2 diabetes mellitus.