In particular, a single intracerebroventricular (i.c.v.)injection of FGF1 induces remission of diabetic hyperglycemia that lasts for weeks or even months in both mouse (Lepob/ob and LepRdb/db) and rat (Zucker diabetic fatty [ZDF]) models of T2D. This evidence concerns the gene FGF1 and type 2 diabetes mellitus.