By consulting the literature, patients with insulinoma will have changes in plasma glucose, C-peptide, and insulin due to the massive secretion of insulin [11–14], and 72% of patients will gain weight [15], we selected indicators related to the assessment of insulin, including insulin, plasma glucose, C-peptide, and HbA1c concentrations, as well as patient demographic and clinical characteristics. This evidence concerns the gene INS and pancreatic insulinoma.