In a mouse model of PTSD, a strong reduction of miR-15a-5p, miR-497a-5p, miR-511-5p, and let-7d-5p levels in the medial prefrontal cortex were correlated with two key PTSD-related genes, FKBP5 and BDNF (Fig. 1) [250]. The gene discussed is FKBP5; the disease is post-traumatic stress disorder.