Subsequently, we examined the downstream target of XBP1.The levels of HIF-1a in relatively low eosinophilic infiltration tissue samples were higher than those in control and eosinophilic CRSwNP samples [24], and HIF-1a is related to neutrophilic inflammation and glucocorticoid resistance in CRSwNP patients [25]. This evidence concerns the gene HIF1A and chronic rhinosinusitis with nasal polyps.