It has been suggested that CRSwNP is related to underlying T helper 2- (Th2-) driven inflammation (producing IFN-γ), while CRSsNP is precipitated by T helper 1- (Th1-) driven inflammation (secreting IL-4, IL-5, and IL-13) [4, 5]. This evidence concerns the gene IL4 and chronic rhinosinusitis without nasal polyps.