The immunohistochemical method was used to determine the degree of lesions, vascular endothelial growth factor (VEGF) expression was observed, microvessel density (MVD) value was calculated, the effect on angiogenesis and cell proliferation in breast cancer was explored, and its biological basis and diagnostic value were understood to provide reasonable and correct treatment options for clinical treatment [10]. This evidence concerns the gene VEGFA and breast carcinoma.