The predicted results from the ChEA3 databases showed that JUN or JUND might be the transcription factor for TXNIP or GADD45A, and thus, we hypothesized that WT1 may indirectly regulate the expression of TXNIP or GADD45A by regulating JUN or JUND and thus inhibit the proliferation of RCC cells. This evidence concerns the gene TXNIP and renal cell carcinoma.