This study detected five target genes (IL-1β, STAT3, CAT, PTGS2, and HMOX1) to further study the effects of quercetin, luteolin, kaempferol, cryptotanshinone, and naringenin on the expression of related genes in steroid-induced avascular necrosis of the femoral head. This evidence concerns the gene PTGS2 and avascular necrosis.