BSP acid glycoprotein is a kind of exist in the matrix, to participate in the trabecular bone, osteoblast combined process is involved in and plays an important role, and the existing research indicates that BSP high expression of bone metastases in breast cancer and is a sign of poor prognosis in patients with tumor; the research results show that the group of patients with bone metastasis BSP level is obviously higher, consistent with previous studies [17]. The gene discussed is IBSP; the disease is bone metastasis.