Apo-A1 mimetic peptide D-4F, ω-3 polyunsaturated fatty acids, and the powdered roots and/or extract of Saussurea lappa (costus) are suggested means for resuming HDL-ApA1 physiological activity aiming at protecting elderly and chronically ill patients and reducing the morbidity of COVID-19. The gene discussed is APOA1; the disease is COVID-19.