CASP3 and Sepsis: However, Bax, caspase-3, and BIM were upregulated, the expression levels of Bax, caspase-3, and BIM were upregulated, the BCL-2 expression level was downregulated, and the CD4+ T cell apoptosis rate significantly increased in the lck-TSC1 sepsis mice (Figure 5(b) and Figure 6(c)).