TNF and cardiovascular disorder: TNFi use is associated with decreased incidence of CAD in patients with RA and no previous cardiovascular disease (CVD). Use of TNF inhibitors for >16.1 months was associated with a relative risk for CAD of 0.18 (95% CI: 0.06-0.50) and CVD of 0.31 (95% CI: 0.15-0.65) compared to the reference group