TP53 and neoplasm: The clustering GSEA results revealed significant enrichment in the majority of immune and tumor-associated signaling pathways, including NOD-like receptor, JAK-STAT, P53, natural killer cell-mediated cytotoxicity, MAPK, Fc-γR-mediated phagocytosis, and RIG-I-like and TOLL-like receptor signaling pathways (Figure 2(e), Additional file 2: Figure S2(c)-(j)).