NOS3 and Hypoglycemia: Interestingly, insulin treatment significantly increased eNOS expression in the hypoglycemia groups compared with DM (p < 0.05), and expression was higher in the RH-DM than in the H-DM group (DM 0.54-, H-DM 1.13-, and RH-DM 1.76-fold compared with controls; p < 0.05).