Interestingly, insulin treatment significantly increased eNOS expression in the hypoglycemia groups compared with DM (p < 0.05), and expression was higher in the RH-DM than in the H-DM group (DM 0.54-, H-DM 1.13-, and RH-DM 1.76-fold compared with controls; p < 0.05). This evidence concerns the gene NOS3 and diabetes mellitus.