As shown in Figures 3(a) and 3(b), there were high expression levels of KPNA2, KIF2C, SPP1, and LPCAT1 genes (p < 0.001) but a low expression level of FMO3 (p < 0.001) in HCC tissues compared with normal tissues within TCGA-LIHC cohort. This evidence concerns the gene SPP1 and hepatocellular carcinoma.