Moreover, GSK-J4 suppressed the IL-1β-mediated increase in the expression of the cartilage-degrading matrix metalloproteinases 9 (MMP9) and 13 (MMP13) and ADAMTS5 in HACs and, therefore, has the potential to attenuate cartilage loss in osteoarthritis patients [66]. This evidence concerns the gene MMP9 and osteoarthritis.