Inhibiting KDM6A/B with GSK-J4 has been shown to inhibit the proliferation of the luminal breast cancer cell lines MCF7 and MDA-MB-231, with the poorly differentiated triple-negative MDA-MB-231 cells showing greater resistance to the anti-proliferative effect of GSK-J4 [39]. The gene discussed is KDM6A; the disease is breast cancer.