KDM6B and neuroblastoma: They also showed that ectopic overexpression of KDM6B considerably inhibited the proliferation of human neuroblastoma cell lines and promoted their neuronal differentiation as implied by extensive outgrowth of neurites, including neuronal axons and dendrites, associated with the upregulation of the neuronal differentiation-promoting genes NEFM, GFRA3 and RET [31].