This is supported by the finding that KDM6A/B inhibition with GSK-J4 promoted survival in mice with E. coli-induced sepsis by dampening the inflammatory response, including the production of the pro-inflammatory cytokines IL-1β, TNFα, IL-6 and CCL2, and directly suppressing the growth of E. coli [88]. Here, KDM6A is linked to Sepsis.