Strikingly, KDM6B but not KDM6A expression was found to be increased in damaged cartilage compared to undamaged cartilage derived from the same knees of osteoarthritis patients undergoing knee replacement surgery [63, 66], implicating KDM6B in articular cartilage damage and loss in osteoarthritis and contradicting the decreased KDM6B expression reported by Dai et al. (2017) [64]. Here, KDM6A is linked to osteoarthritis.