ZFHX4 and metastatic colorectal cancer: Fèvre-Montange et.al firstly reported that ZFHX4 was highly expressed in parapineal tumors, a rare but aggressive type of pineal region tumor, using oligonucleotide arrays in 2006 [39].Similarly, Wang et.al found that ZFHX4 amplifications were more common in the metastatic colorectal cancer patients than those without metastases [40].