Eskandari et al. reported that Kv11.1 channel reprogrammed EMT in colon cancer via regulating zinc finger homobox proteins [49], suggesting that ZFHX4 might also act as a mediator converting the signals from ion transporter activation to EMT occurrence and ECM reprogramming in ovarian cancer. The gene discussed is ZFHX4; the disease is malignant colon neoplasm.