As such, physical activity has been associated with slower rates of cognitive decline and lower risk of dementia [12], and with increased levels of peripheral serum or plasma BDNF [13], and social interactions [14] and environmental enrichment [15] improve memory deficits in AD-like animal models through BDNF-dependent hippocampal neurogenesis, the exploratory analysis of the SUPERBRAIN [10] also showed that serum BDNF levels were significantly increased in the facility-based multidomain intervention (FMI) compared to the control group. This evidence concerns the gene BDNF and dementia.