SH3PXD2A and cancer: To rigorously confirm that invadopodia function is required for cooperative invasion of cancer cells, we stably eliminated invadopodia in 4T1-mScarlet cells, using a knockdown of mouse Tks5 (Tks5-KD)13, and established the corresponding control (Tks5-CTL) cell line (Fig. 6a, top, 78.1% knockdown efficiency).