Bioinformatics analysis using UALCAN indicated that SIRT6 expression was upregulated in lung cancer tissues compared to normal lung tissues (sample number in LUSC group: normal 52, primary tumor 503, p < 0.001; Fig. 1A) (sample number in LUAD group: normal 59, primary tumor 515, p < 0.001; Fig. 1B). The gene discussed is SIRT6; the disease is lung carcinoma.