ALDH2 and adverse effect: Our detection of ALDH2 is interesting as this gene is not only associated with alcohol dependence in humans, but is also an important regulator of dopaminergic and serotonergic systems implicated in protective effects against opioids addiction48 and exhibits important interactions with the mescaline receptor 5-HT2A, responsible of the psychotropic effects and involved in several mental pathologies49,50.