Among these overlapping genes, we noticed that plenty of genes (NOTCH1, NKX2-1, BCL11B, RUNX1, FBXWT, STAT5B, DNM2, AKT1/2, MTOR, ABL1, DNMT3A, and RPL11) were associated with T-ALL pathogenesis(Supplementary Fig. 5B) [22]. This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.