NOTCH1 and acute lymphoblastic leukemia: However, it is noted that IGF2BP2 interference or JX5 treatment induced apoptosis of human T-ALL cell lines (Supplementary Figs. 4C and 9E), while most GSIs inhibit cells proliferation mainly by arresting cell cycle [33]; additionally, JX5 treatment also affected the NOTCH1 independent T-ALL cell lines LOUCY viability slightly (Supplementary Fig. 9J), implying that inhibiting IGF2BP2 have some non-NOTCH1 effects.