The prefrail group had significantly lower mean values for the TBV-to-eTIV ratio and significantly higher mean values for the WMHV-to-eTIV ratio compared with the robust group after adjustment for age, sex, hypertension, diabetes mellitus, serum LDL and HDL cholesterol levels, education level, GDS score, ApoE E4 carrier status, and MMSE score. The gene discussed is APOE; the disease is Hypertension.