In the current investigation, multivariate logistic regression analysis revealed that the prediction of the D-dimer, LDH and AT-III can be contemplated as excellent independently predictors of the severity risk in COVID-19, with a cut off (2.0 ng/L, 500 IU/L, and 75%) and AUC of (0.940, 0.848, 0.781) respectively by ROC curve analysis. The gene discussed is SERPINC1; the disease is COVID-19.