For instance, silencing of cZNF292 suppresses tube formation in glioma U87MG and U251cells by downregulating the levels of VEGFR-1/2, phosphorylated VEGFR-1/2 (p-VEGFR-1/2), VEGF-A, EGF, TGF-β1 and EGFR [60]. This evidence concerns the gene FLT1 and central nervous system cancer.