In addition, has-circRNA-403658, formed via back-spliced between the 1st and 4th exon of its host gene-ZNF292, exhibits HIF1α-dependent expression in bladder cancer cells under hypoxia, and promotes bladder cancer cell growth by reducing cell apoptosis and activating LDHA-mediated aerobic glycolysis [29]. The gene discussed is HIF1A; the disease is urinary bladder carcinoma.