PRKAA1 and Alzheimer disease: Catalytically active AMPK has been shown to co-localize with phosphorylated-S262 hTau in brains of AD patients38, and previous work highlights that hyperactivation of AMPK by Aβ42o and/or other AMPK-like kinases such as NUAK1 leads to Tau phosphorylation on two of its serine residues (S262 and S3562,86) embedded in the R1 and R4 microtubule binding domains, respectively87.