The J20 mouse line is a powerful model to study the effect of amyloidosis in AD pathogenesis, as it expresses the human Amyloid Precursor Protein (APP) carrying two mutations found in familial forms of AD (APPSwe,Ind i.e., KM670.NL and V717F called J20 model thereafter), and shows Aβ42o accumulation in the hippocampus8. This evidence concerns the gene APP and amyloidosis.