Catalytically active AMPK has been shown to co-localize with phosphorylated-S262 hTau in brains of AD patients38, and previous work highlights that hyperactivation of AMPK by Aβ42o and/or other AMPK-like kinases such as NUAK1 leads to Tau phosphorylation on two of its serine residues (S262 and S3562,86) embedded in the R1 and R4 microtubule binding domains, respectively87. The gene discussed is MAPT; the disease is Alzheimer disease.