ULK1 and amyloidosis: Another potential difference between our present results and ref. 37 results is that our in vitro and in vivo results examine the influence of Aβ42o-mediated spine loss using acute (24 h) exposure in vitro or early stages of Aβ42o accumulation in the J20 model (3 months i.e., before amyloid plaque appearance) whereas the Fang et al. paper examine mostly ULK1 and mitophagy events in “late” AD patients at a point where neuronal viability and therefore autophagosome clearance might be compromised41.