We also observed increases in the percentages of tumor-infiltrating lymphocytes (TIL) producing IFNγ and activation marker Granzyme B (GZMB), and a reduced fraction of FOXP3+ T regulatory cells (Fig. 6h–j and Supplementary Fig. 5b), whereas the fraction of CD11b+ Ly6G+ neutrophils and F4/80+ CD11b+ macrophages remained constant (Supplementary Fig. 5c). This evidence concerns the gene GZMB and neoplasm.