To investigate whether EV-TβRII could rescues the tumor growth rate in the absence of TβRII, we transplanted 4T1 cells expressing a doxycycline (DOX)-inducible shRNA targeting TβRII in mice followed by DOX administration and tail vein injection of in vitro collected TEVs from either their WT or TβRII null counterparts (Supplementary Fig. 6a). This evidence concerns the gene TGFBR2 and neoplasm.