Notably, when comparing breast cancer patients to healthy donors, the receiver operating characteristic (ROC) curves showed that the percentage of TβRII+ crEVs could be a nice classifier with an area under curve (AUC) of 0.872 exhibiting a sensitivity of 93.48% and a specificity of 90%, an accuracy of 92.42%, and with a positive predictive value of 95.55% and negative predictive value of 85.71% (Fig. 3f and Supplementary Table 3). The gene discussed is TGFBR2; the disease is breast cancer.