In addition to the original report, several recent studies have confirmed the association of APOE4 with severity and mortality of COVID-19 in large cohorts.37,38 However, APOE was not identified as a critical host gene for COVID-19 in a recent whole genome sequencing study.4 Another study failed to identify a linkage between APOE locus and COVID-19 severity in stratified analyses by dementia status.39 The decrepancies in outcomes from different genetic studies may be partillay due to varying criteria in defining COVID-19 severity. Here, APOE is linked to dementia.