Quantitative analysis of HFs from Ctrl, Ror2 cKO, β-cat cKO, and Ror2/β-cat dKO mice demonstrated that the phenotype displaying enlarged sebaceous glands (SGs) was only observed in Ror2/β-cat dKO HFs and that more than a half of Ror2/β-cat dKO HFs showed enlarged SGs accompanied with aberrant HF structure or diminished bulge compartments (Fig. 6c, bottom). The gene discussed is CAT; the disease is Hand-foot syndrome.