PRRT2 and Hand-foot syndrome: We have showed that ROR2 expression was elevated in β-cat cKO HFSCs at late telogen and aged HFs (Supplementary Fig. 6); interestingly, we also detected increased PKC expression in these β-cat cKO HFSCs of late telogen HFs (Supplementary Fig. 10a) as well as at aged animals (Supplementary Fig. 10b).