ROR2 and Hand-foot syndrome: However, at the onset of the 2nd anagen while Ror2 cKO HFs continuously showed the delay of anagen entry (Fig. 1e) and β-cat cKO HFs were arrested at telogen (Fig. 6a and Supplementary Fig. 7a), Ror2/β-cat dKO HFs failed to initiate hair cycle and displayed signs of massive sebocyte differentiation (Fig. 6c and Supplementary Fig. 7b).