In agreement, the elevated Ror2 expression in β-cat cKO HFSCs at late telogen and aged HFs was confirmed by whole-mount immunostaining, showing that ROR2 expression was higher in the bulge of β-cat cKO HFs than Ctrl HFs at late 2nd telogen (Supplementary Fig. 6a) as well as at aged animals (Supplementary Fig. 6b). The gene discussed is ROR2; the disease is Hand-foot syndrome.