Consistent with a key role of NMDAR and mGluR5 signaling in modulating a wide range of behaviors relevant to neuropsychiatric disorders, here we explored whether the congenital depletion of D-Asp could affect some of these in vivo phenotypes at juvenile/young adult phase (6–8 weeks), including stereotypic behavior, motor activity, motor learning and coordination, sensorimotor gating, anxiety-related responses, compulsivity and social behavior. Here, GRM5 is linked to Anxiety.