Moreover, miR-100 and miR-16 shuttled by BMMSC-EVs suppressed breast cancer cells angiogenesis in vitro through modulating the mTOR/HIF-1α/VEGF signaling axis (Pakravan et al., 2017), suppressed angiogenesis by down-regulating VEGF expression in breast cancer cells (Lee et al., 2013), respectively. The gene discussed is HIF1A; the disease is breast cancer.