For example, BMMSC-EVs containing miR-206 inhibits osteosarcoma progression by targeting transformer 2β (TRA2B) (Zhang et al., 2020), and containing miR-9-3p inhibits the growth and metastasis of bladder cancer by targeting ESM1 (Endothelial cell specific molecule 1) gene expression (Cai et al., 2019). This evidence concerns the gene ESM1 and urinary bladder carcinoma.