For example, BMMSC-EVs containing miR-206 inhibits osteosarcoma progression by targeting transformer 2β (TRA2B) (Zhang et al., 2020), and containing miR-9-3p inhibits the growth and metastasis of bladder cancer by targeting ESM1 (Endothelial cell specific molecule 1) gene expression (Cai et al., 2019). The gene discussed is ESM1; the disease is osteosarcoma.