CD226 and neoplasm: found that IL-2 or IL-15-stimulated NK cells derived EVs exert their cytolytic effect against tumor by delivering IFN-γ, lymphocyte function-associated antigen-1 (LFA-1), DNAX accessory molecule-1 (DNAM1) and programmed cell death protein (PD-1) (Di Pace et al., 2020).