Furthermore, Guo et al. (2021) reported that CamKII/Creb signaling protects RGCs and induces optic nerve regeneration in adult mice after excitotoxic NMDA treatment or axonal injuries, and transduction of a constitutively active form of CamKII (T286D) into adult RGCs provides long-term protection to RGC and their axons in glaucoma and ONC injury mouse models (Guo et al., 2021). This evidence concerns the gene CREB1 and glaucoma.