The Dyrk1A gene has been shown to play a major role in DS; its overexpression induces changes to synaptic plasticity in both the hippocampus and prefrontal cortex (Ahn et al, 2006; Thomazeau et al, 2014; Atas-Ozcan et al, 2021). The gene discussed is DYRK1A; the disease is Dravet syndrome.