H1-1 and bipolar disorder: Interestingly, human homologs of Hist1h1a (HIST1H1A) and Hist1h3a (HIST1H3A) that are part of this nucleosome-related network are included in a locus associated to bipolar disorder and schizophrenia, according recent Genome Wide Association Studies (Mullins et al, 2021; Trubetskoy et al, 2022).