Moreover, PFKFB4 is induced by hypoxia, is required for survival and proliferation of normal thymocytes (Houddane et al, 2017) as well as of several cancer cell lines such as lung, breast, and colon adenocarcinomas and prostate and bladder cancer (Ros et al, 2012; Yun et al, 2012; Chesney et al, 2014; Zhang et al, 2016b). Here, PFKFB4 is linked to cancer.