Furthermore, cardiac-specific (Ashrafian et al, 2010; Ikeda et al, 2015; Ishihara et al, 2015; Song et al, 2015) and brain-specific (Ishihara et al, 2009; Wakabayashi et al, 2009) ablation of DRP1 leads to lethal dilated cardiomyopathy and defective cerebellar development with early postnatal death, respectively. Here, DNM1L is linked to dilated cardiomyopathy.