Cardiac involvement in patients with DNM1L-related mitochondrial disease has previously been postulated because a C452F substitution in mouse DRP1 (position p.Cys446Phe in human DRP1 NP_036192.2) was shown to cause dilated cardiomyopathy (Cahill et al, 2015). The gene discussed is DNM1L; the disease is inborn mitochondrial metabolism disorder.