Therefore,all enzymes that participate in the de novo purinebiosynthesis pathway can be considered potential targets for anticancertherapy.2 Indeed, PAICS is overexpressedin several types of cancer and has been shown to play an importantrole in cancer cell proliferation and invasion, correlating thereforewith poor prognosis.3 Accordingly, PAICShas been explored as a potential cancer therapy target. The gene discussed is PAICS; the disease is cancer.