Similarly, P. anaerobius directly binds to the surface receptor integrin α2/β1 (ITGA2/ITGB1) of intestinal epithelial cells through its surface protein putative cell wall binding repeat 2 (PCWBR2) to activate the tumor-promoting pathway PI3K-Akt-NF-κB, resulting in hyperproliferation of cancer cells [20], [21]. Here, NFKB1 is linked to cancer.