To further explore enhancing an antigen-specific response across antigen classes, pAntp was conjugated to the tumor-associated antigen Trp1 from the immunoresistant B16F10 murine melanoma, to three neoantigens identified from the immunosensitive GL261 and immunoresistant CT2A murine glioma models (Nsl1, Tbrg4, and Hspa14) (SI Appendix, Fig. S5), as well as the human papillomavirus oncoviral antigens E6 and E7 (Fig. 2B). The gene discussed is TBRG4; the disease is central nervous system cancer.